Patient Recruitment for Clinical Trials

At ThreeWire, we do not believe in experimenting with our customers’ money. Our years of experience enable careful planning and modeling as well as field-testing at selected sites and geographies. When time permits this is not only wise but essential to success. And it doesn’t have to consume an excess of time.

You, your sites and patients want and need to know what they can expect. We collaborate to define these expectations in advance and then hold ourselves to the resulting performance standards.

Following are two examples of how we’ve performed with recent projects:

Respiratory disease study at 24 sites - 2009
Synopsis: ThreeWire was contracted to complete enrollment two months ahead of sponsor’s forecasted completion date.

Results: ThreeWire completed enrollment nearly four months ahead of sponsor’s forecasted completion date (two months ahead of it’s own targeted date) while using a little more than half of the planned outreach budget.

1. A single exclusion criteria in the study protocol resulted in eliminating more than triple the originally projected screen failure rate.

Cardiology study at 46 sites – 2009
Synopsis: ThreeWire was contracted to assist with jump-starting enrollment for this large study to ensure it did not fall behind projections early in its conduct.

Results: Enrollment targets have been achieved with the number of enrollments from this program still increasing as site screenings continue at the present time.

1. ThreeWire analyzed original media vendor estimates and revised them by approximately 100%. These final estimates proved to be within 10% of actual results.
2. Enrollments are increasing as referred patients continue to be screened at sites.

The foundation for our performance planning and management process is built upon a forecast which is developed in advance of each project from both qualitative and quantitative modeling of patient enrollment. A qualitative model is constructed through identifying the most efficient process flow for patient candidates from initial identification all the way through to either enrollment or disqualification and then mapping this in a flow chart document. We then overlay the flow chart with the forecasted necessary work units by function to complete each step. A quantitative model is then built using a regression analysis that integrates data from previous programs sharing similar characteristics. Combining the two models results in a forecasted patient funnel with costs, times and expected enrollments. The tracking and reporting tools are then built from these models and are used for capturing metrics from outreach all the way to individual site performance.

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At ThreeWire, we do not believe in experimenting with our customers’ money. Our years of experience enable careful planning and modeling as well as field-testing at selected sites and geographies. When time permits this is not only wise but essential to success. And it doesn’t have to consume an excess of time. You, your sites and patients want and need to know what they can expect. We collaborate to define these expectations in advance and then hold ourselves to the resulting performance standards. Following are two examples of how we’ve performed with recent projects: Respiratory disease study at 24 sites - 2009 Synopsis: ThreeWire was contracted to complete enrollment two months ahead of sponsor’s forecasted completion date. Results: ThreeWire completed enrollment nearly four months ahead of sponsor’s forecasted completion date (two months ahead of it’s own targeted date) while using a little more than half of the planned outreach budget. 1. A single exclusion criteria in the study protocol resulted in eliminating more than triple the originally projected screen failure rate. Cardiology study at 46 sites – 2009 Synopsis: ThreeWire was contracted to assist with jump-starting enrollment for this large study to ensure it did not fall behind projections early in its conduct. Results: Enrollment targets have been achieved with the number of enrollments from this program still increasing as site screenings continue at the present time. 1. ThreeWire analyzed original media vendor estimates and revised them by approximately 100%. These final estimates proved to be within 10% of actual results. 2. Enrollments are increasing as referred patients continue to be screened at sites. The foundation for our performance planning and management process is built upon a forecast which is developed in advance of each project from both qualitative and quantitative modeling of patient enrollment. A qualitative model is constructed through identifying the most efficient process flow for patient candidates from initial identification all the way through to either enrollment or disqualification and then mapping this in a flow chart document. We then overlay the flow chart with the forecasted necessary work units by function to complete each step. A quantitative model is then built using a regression analysis that integrates data from previous programs sharing similar characteristics. Combining the two models results in a forecasted patient funnel with costs, times and expected enrollments. The tracking and reporting tools are then built from these models and are used for capturing metrics from outreach all the way to individual site performance.		Articles Accelerating Patient Recruitment for Medical Device Clinical TrialsBy Mark Summers Disease of the moment: More care is the ultimate goal AMNews ThreeWire: Marketing Meets Patient Recruiting for Device Trials Windhover Information, Inc.